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Did you mean proc and bone (11,242 results)?
Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs.
Gan Y, He J, Zhu J, Xu Z, Wang Z, Yan J, Hu O, Bai Z, Chen L, Xie Y, Jin M, Huang S, Liu B, Liu P. Gan Y, et al. Bone Res. 2021 Aug 16;9(1):37. doi: 10.1038/s41413-021-00163-z. Bone Res. 2021. PMID: 34400611 Free PMC article.
The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) homeostasis. Notably, in the NP, a PROCR(+) resident progenitor population showed enriched colony-forming unit-fibroblast (CFU …
The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix …
Spatially multicellular variability of intervertebral disc degeneration by comparative single-cell analysis.
Lin P, Yan P, Zhu J, Huang S, Wang Z, Hu O, Jin H, Li Y, Zhang L, Zhao J, Chen L, Liu B, He J, Gan Y, Liu P. Lin P, et al. Cell Prolif. 2023 Oct;56(10):e13464. doi: 10.1111/cpr.13464. Epub 2023 Apr 6. Cell Prolif. 2023. PMID: 37025067 Free PMC article.
The frequencies and signatures of these cell clusters fluctuate with IDD. Notably, the chondrogenic differentiation programme of PROCR(+) progenitor cells is altered by IDD, while notochord cells turn to stemness exhaustion. ...
The frequencies and signatures of these cell clusters fluctuate with IDD. Notably, the chondrogenic differentiation programme of PROCR …
Function of stem cells in radiation-induced damage.
Liu Y, Liu Z, Hu L, He L, Yang L, Qin Z, Xie Y, Peng X, Dai L. Liu Y, et al. Int J Radiat Biol. 2023;99(10):1483-1494. doi: 10.1080/09553002.2023.2188935. Epub 2023 Mar 23. Int J Radiat Biol. 2023. PMID: 36912588 Review.
In the pancreas, beta-cells as well as protein C receptor positive (Procr) cells are expected to be key cells in the treatment of diabetes. In the bone marrow, a variety of cytokines such as CXC-chemokine ligand 12 (CXCL12) and stem cell factor (SCF), contribute to …
In the pancreas, beta-cells as well as protein C receptor positive (Procr) cells are expected to be key cells in the treatment of dia …
ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration.
Umemoto T, Johansson A, Ahmad SAI, Hashimoto M, Kubota S, Kikuchi K, Odaka H, Era T, Kurotaki D, Sashida G, Suda T. Umemoto T, et al. EMBO J. 2022 Apr 19;41(8):e109463. doi: 10.15252/embj.2021109463. Epub 2022 Mar 1. EMBO J. 2022. PMID: 35229328 Free PMC article.
In order to support bone marrow regeneration after myeloablation, hematopoietic stem cells (HSCs) actively divide to provide both stem and progenitor cells. ...After 5-fluorouracil-induced myeloablation, HSCs highly expressing endothelial protein C …
In order to support bone marrow regeneration after myeloablation, hematopoietic stem cells (HSCs) actively divide to provide both ste …
Extravascular coagulation in hematopoietic stem and progenitor cell regulation.
Nguyen TS, Lapidot T, Ruf W. Nguyen TS, et al. Blood. 2018 Jul 12;132(2):123-131. doi: 10.1182/blood-2017-12-768986. Epub 2018 Jun 4. Blood. 2018. PMID: 29866813 Free PMC article. Review.
We review the evidence that these vascular-protective mechanisms have nontraditional roles in hematopoietic stem cell (HSC) maintenance in their physiological bone marrow (BM) niches at steady-state and under stress. Expression of coagulation factors and the extrinsic coag …
We review the evidence that these vascular-protective mechanisms have nontraditional roles in hematopoietic stem cell (HSC) maintenance in t …
Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling.
Gur-Cohen S, Kollet O, Graf C, Esmon CT, Ruf W, Lapidot T. Gur-Cohen S, et al. Ann N Y Acad Sci. 2016 Apr;1370(1):65-81. doi: 10.1111/nyas.13013. Epub 2016 Mar 1. Ann N Y Acad Sci. 2016. PMID: 26928241 Free PMC article. Review.
The common developmental origin of endothelial and hematopoietic cells is manifested by coexpression of several cell surface receptors. Adult murine bone marrow (BM) long-term repopulating hematopoietic stem cells (LT-HSCs), endowed with the highest repopulation and self-r …
The common developmental origin of endothelial and hematopoietic cells is manifested by coexpression of several cell surface receptors. Adul …
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T. Gur-Cohen S, et al. Nat Med. 2015 Nov;21(11):1307-17. doi: 10.1038/nm.3960. Epub 2015 Oct 12. Nat Med. 2015. PMID: 26457757 Free PMC article.
We report that signaling cascades that are traditionally viewed as coagulation related also control retention of endothelial protein C receptor-positive (EPCR(+)) LT-HSCs in the bone marrow and their recruitment to the blood via two pathways med …
We report that signaling cascades that are traditionally viewed as coagulation related also control retention of endothelial prote …
Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia.
Zheng X, Li W, Song Y, Hu Y, Ferrell GL, Esmon NL, Esmon CT. Zheng X, et al. J Thromb Haemost. 2007 Jul;5(7):1394-400. doi: 10.1111/j.1538-7836.2007.02592.x. Epub 2007 Apr 18. J Thromb Haemost. 2007. PMID: 17445091 Free article.
BACKGROUND: Activated protein C (APC) protects the host from severe sepsis. Endothelial protein C receptor (EPCR) is expressed on both hematopoietic leukocytes and non-hematopoietic endothelium, and plays a key role in protein C activation. ...Procr …
BACKGROUND: Activated protein C (APC) protects the host from severe sepsis. Endothelial protein C receptor (EPCR …
Apoptosis of Hematopoietic Stem Cells Contributes to Bone Marrow Suppression Following Chimeric Antigen Receptor T Cell Therapy.
Read JA, Rouce RH, Mo F, Mamonkin M, King KY. Read JA, et al. Transplant Cell Ther. 2023 Mar;29(3):165.e1-165.e7. doi: 10.1016/j.jtct.2022.12.020. Epub 2022 Dec 31. Transplant Cell Ther. 2023. PMID: 36592718 Free PMC article.
This study was conducted to test our hypothesis that delayed bone marrow recovery following CAR-T therapy is caused by elevation of proinflammatory cytokines, leading to apoptosis and depletion of hematopoietic stem and progenitor cells (HSPCs). ...Gene set enrichment anal …
This study was conducted to test our hypothesis that delayed bone marrow recovery following CAR-T therapy is caused by elevation of p …
Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation.
Couzi L, Pitard V, Moreau JF, Merville P, Déchanet-Merville J. Couzi L, et al. Front Immunol. 2015 Jan 21;6:3. doi: 10.3389/fimmu.2015.00003. eCollection 2015. Front Immunol. 2015. PMID: 25653652 Free PMC article. Review.
Recently, an unconventional T cell population (collectively designated as Vdelta2(neg) gammadelta T cells) has been characterized during the anti-CMV immune response in all solid-organ and bone-marrow transplant recipients, neonates, and healthy people. ...A multiple of Vd …
Recently, an unconventional T cell population (collectively designated as Vdelta2(neg) gammadelta T cells) has been characterized during the …
63 results